AmnioFix Sports Medicine 20mg, 40mg, 100mg

AmnioFix Sports Medicine 20mg, 40mg, 100mg

Human amniotic membrane is a thin, collagenous membrane derived from the placenta, the area in which the human fetus grows and develops within the mother’s uterus.

  • Modulates Inflammation
  • Reduces Scar Tissue Formation
  • Enhances Healing of Soft Tissue

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Since 2006, as the premier leader in regenerative medicine, MiMedx® has been dedicated to advancing healing through innovative biomaterial products and bioimplants. To date, approximately 20 clinical and scientific papers have been published in peer-reviewed journals on our PURION Processed amniotic membrane allografts.

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Human amniotic membrane consists of multiple layers. AmnioFix Sports Med is a minimally manipulated, dehydrated, non-viable cellular amniotic membrane allograft that contains multiple extracellular matrix proteins, growth factors, cytokines, and other specialty proteins present in amniotic tissue to enhance healing. AmnioFix Sports Med allografts are human tissue products and appearance may vary between donors. Variations in color (tan to light brown) and opacity are normal due to the nature of human tissue. AmnioFix is a bioactive tissue matrix composed of human amnion/chorion membrane for homologous use. AmnioFix contains more than 57 different growth factors, cytokines, and chemokines including interleukins (IL-1ra, lL-4, and IL-10) to modulate inflammation. AmnioFix contains these natural growth factors and collagens, which are core building blocks to help enhance healing.

Growth Factors Present in AmnioFix

Over 57 different growth factors, specialized cytokines, and enzyme inhibitors have been identified in AmnioFix, including the following which are some of the most notable growth factors that help enhance soft tissue healing:

  • Transforming Growth Factor Beta (TGF-ß1) - Promotes
  • normal soft tissue healing and reduced scar formation
  • Fibroblast Growth Factor (FGF) - Promotes cellular proliferation and important for collagen matrix formation
  • Platelet Derived Growth Factors (PDGF AA & BB) - Promote cell proliferation in connective tissue and enhance soft tissue healing
  • Extracellular Components in AmnioFix
  • The Extracellular Matrix of amniotic membrane is composed of three major classes of biomolecules:
  • Structural proteins: collagen types I, III, IV, V and VII, and elastin
  • Specialized proteins: fibronectin, TIMPs†, and laminins
  • Proteoglycans: formed when GAGS are linked to core proteins

In addition to the properties of the growth factors present which modulate inflammation, AmnioFix can also stimulate native cells to upregulate their production of immunomodulatory factors.

PURION® Processed dehydrated human amnion/chorion membrane (dHACM) contains extracellular matrix, stimulates multiple cell types to migrate and proliferate, and acts as a Stem Cell Magnet™ drawing mesenchymal stem cells and hematopoietic stem cells from tissues to the site of injury.

Recruited stem cells modulate the body’s inflammatory response releasing their own growth factors, cytokines, and paracrine factors to begin the healing process.

Boost

Healing

No

Immune Response

Easy

Allograft

5

Year Shelf Life