OrthoFlo Sport Amniotic Fluid Allograft .5 ml, 1.0 ml, 2.0 ml, 4.0 ml

OrthoFlo Sport Amniotic Fluid Allograft .5 ml, 1.0 ml, 2.0 ml, 4.0 ml

OrthoFlo Sport is an amniotic fluid allograft for homologous use to protect and cushion, provide lubrication for enhanced mobility, and reduce inflammation.

  • Protect & cushion
  • Provide lubrication for enhanced mobility
  • Reduce inflammation

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OrthoFlo Sport is procured and processed in the United States according to standards and/or regulations established by the American Association of Tissue Banks (AATB) and the United States Food & Drug Administration (FDA).

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Amniotic fluid, in utero, naturally functions to protect, cushion and lubricate.  Key elements of amniotic fluid include growth factors, carbohydrates, proteins, lipids, electrolytes, and other nutrients, as well as hyaluronic acid (HA), a principle component that provides viscosity and lubrication in the synovial fluid that surrounds joints.  Since 2006, as the premier leader in regenerative medicine, MiMedx® has been dedicated to advancing healing through innovative biomaterial products and bioimplants.

Regulatory FactorsOrthoFlo Sport contains an array of well-known regulatory proteins, growth factors, cytokines, and chemokines that are naturally occurring in amniotic fluid and the fluid surrounding many joints. Some of the bioactive factors contained within OrthoFlo Sport include:

  • Interleukin 1 Receptor Antagonist (IL-1ra): Antagonist of IL-1 signaling which is known to be involved in cartilage degeneration
  • Tissue Inhibitor of Metalloproteinases (TIMPs): Inactivates a number of matrix metalloproteinases responsible for cartilage degradationBiological ActivityProliferation and hyaluronic acid production by cells in response to OrthoFlo Sport were measured in normal human synoviocytes. Normal human synoviocytes from healthy donors were cultured in the presence of OrthoFlo Sport, either at 0.2 or 0.8 mg/mL. OrthoFlo Sport significantly increased cell number after 3 days compared to basal medium, indicating that OrthoFlo Sport promoted proliferation of human synoviocytes.


year shelf life




Use Only


Sterile Saline