Adipose
Adipose
Adipose is used in regenerative medicine procedures because mesenchymal stem cells can be isolated from almost every tissue in the human body. The central connecting aspect to explain this fact is that all of these tissues are vascularized and that every blood vessel in the body has mesenchymal cells in abluminal locations. These perivascular cells can be summarily called Pericytes. Adipose-derived MSCs are being used therapeutically because they undergo homing to sites of inflammation or tissue injury, and they secrete massive levels of bioactive agents that are both immunomodulatory and trophic.
Adipose tissue, commonly known as fat, is widely used in regenerative medicine due to its rich mesenchymal stem cells (MSCs) source. MSCs, which can differentiate into various cell types such as bone, cartilage, and fat, can be isolated from nearly every tissue in the human body. The unifying feature of all these tissues is their vascularization—every tissue with blood vessels contains mesenchymal stem cells.
These MSCs reside in specific locations around blood vessels, known as the abluminal side, where they are referred to as perivascular cells, or more specifically, Pericytes. When activated, pericytes play a crucial role in supporting and maintaining the integrity of blood vessels and contribute to the repair and regeneration of surrounding tissues.
Adipose-derived MSCs have become a prominent focus in regenerative therapies due to their unique ability to “home in” on inflammation or tissue injury areas. Once they reach these sites, they begin secreting large amounts of bioactive agents, including cytokines and growth factors, which perform two key functions. First, they act as immunomodulatory agents, meaning they help regulate and calm the immune response, reducing inflammation. Second, they provide trophic support, promoting tissue repair and regeneration by creating a nurturing environment for healing.
This dual action—immunomodulation and tissue repair—makes adipose-derived MSCs a powerful tool in therapeutic applications, especially for conditions involving inflammation or tissue damage. Their widespread use in regenerative medicine stems from their natural ability to accelerate healing and support the body’s regenerative processes.
Low
Risk
FDA
Cleared
Did you know?
MSCs are found as perivascular cells and, even in large vessels ,in the adventitia but, again, not in the generic connective tissue. To best understand the native, functional properties of MSCs, think PERICYTES.
The Do's and Dont's of Adipose
The Do’s
Pre and Post injection protocols should be discussed with your doctor. However, having a healthy diet, being well hydrated, and active will help your recovery. Patients are generally able to resume normal activities within a few days.
